Table 3.

Association between late first-trimester degree of adherence to the six food targets and GDM risk stratified by TCF7L2 rs7903146 genotype. Interaction analysis between genotypes and adherence (n = 856, in crude and adjusted by age, ethnicity, parity, family history of DM and BMI).

		No GDM	GDM	∗Crude OR (95% CI)	∗Adjusted OR (95% CI)	†Crude OR (95% CI)	†Adjusted OR (95% CI)
rs7903146 C/C	Low adherence	46 (76.6)	14 (23.3)	1.00	1.00	1.00	1.00
	Moderate adherence	231 (77.0)	69 (23.0)	0.98 (0.51–1.89)	0.83 (0.42–1.66)	0.98 (0.51–1.89)	0.83 (0.42–1.64)
	High adherence	39 (78.0)	11 (22.0)	0.93 (0.38–2.27)	1.06 (0.42–2.72)	0.93 (0.38–2.27)	1.06 (0.42–2.72)
rs7903146 C/T + T/T	Low adherence	49 (68.0)	23 (31.9)	1.00	1.00	1.54 (0.71–3.35)	1.53 (0.67–3.47)
	Moderate adherence	269 (84.0)	51 (15.9)	0.40 (0.23–0.72)	0.39 (0.21–0.741	0.62 (0.32–1.22)	0.60 (0.29–1.21)
	High adherence	50 (92.6)	4 (7.4)	0.17 (0.05–0.52)	0.15 (0.05–0.48)	0.26 (0.08–0.84)	0.23 (0.07–0.77)
p-interaction				0.035	0.025	0.035	0.025

Data are n(%) Logistic regression analysis by genotype subgroups evaluating degree of adherence to the six food targets and risk of GDM; p-interaction: logistic regression analysis evaluating interactions between degree of adherence and genotypes. ∗ Analysis with no GDM and Low adherence as reference; †Analysis with no GDM, Low adherence and C/C genotype as reference.