Table 3.
Summary of RSV and its combinational chemopreventive effects.
| Ref. | Experimental Models Systems | RSV Combinations | Effects |
|---|---|---|---|
| Bader & Getoff (2006) | Human Breast cancer cells – MCF7 | Mitomycin C (MMC) | Anti-tumor free radical scavenger activity under aerobic conditions in presence of mitomycin ↑ |
| Reiter et al. (2007) | Human Mast Cell line-1 (HMC-1) | Delta-Tocopherol |
Combinations of 50 μM RSV and 50 μM delta-tocopherol resulted: Protein Kinase B (PKB) Ser473-phosphorylation ↓ HMC-1 cell proliferation ↓ |
| Zhang et al. (2014) | Fanconi anemia (FA) murine models | N-acetylcysteine (NAC) | Neither RSV nor NAC could have significant chemopreventive effect in FA mouse models. |
| Yang et al. (2015a, b, c) | Human bronchial epithelial cell line BEAS-2B, 16HBE and Human lung cancer cell lines – A549 and H446. | AK001796 lncRNA |
AK001796 in lung cancer tissues and cells pretreated with RSV resulted: G0/G1 cell cycle arrest ↑ In vitro and In vivo colony formation ↓ Cell growth and proliferation ↓ |
| Li et al. (2016) | Patient derived glioblastoma-initiating cells. | Temozolamide |
Both in vitro and in vivo resulted: Apoptosis ↑ through DNA double stranded breaks, pATM/pATR/p53 pathway activation ↑ cell differentiation ↑ p-STAT3 activity ↓ |
| Hardin et al. (2016) | Anaplastic thyroid cancer cell lines – FRO, Kat18, NTHY-Ori-3, 8505C, papillary thyroid carcinoma cell line BCPAP, TPC-1 Cell line, THJ-16T and THJ-21T | Valproic acid | Stem cell marker - Aldefluor expression ↓ Proliferation ↓ Invasiveness ↓ Apoptosis ↑ Thyroid differentiation markers ↑ |
| Yuan et al. (2017) | Human ovarian carcinoma cell line – A2780 cells | Gemcitabine (GEM) along with Silver nanoparticles-RSV (AgNPs) | Combined GEM and AgNPs exhibited potent apoptotic activity ↑ |
| Dewangan et al. (2017) | Human breast cancer cells (HBCCs) - MCF-7, MCF-10A | Salinomycin | Apoptosis ↑ via reactive oxygen species (ROS) mediated mitochondrial dysfunction. Altered nuclear morphology PARP cleavage ↑, Caspase activation ↑ Modulated MAPK pathway |
| Mukherjee et al. (2018) | C57BL/6 male mice (2–4 months old); GL261 mouse glioblastoma cells | TriCurin: Curcumin, Epicatechin gallate and Resveratrol (4:1:12.5) combination |
In GL261 under In vitro: p53 ↑ apoptosis ↑ In In vivo: Repolarization of M2-like tumor (GBM) associated microglia/macrophages to the tumoricidal M1-like phenotype and intra-GBM recruitment of activated natural killer cells leading to apoptosis of tumor stem cells. |
| Pouyafar et al. (2019) | SKOV3 derived ovarian cancer stem cells In vitro | Doxorubicin (DOX) |
Treated with RSV and DOX at IC50of 55 μM and 25 ηM, respectively resulted: BAX ↑ Caspase 3 ↑ MDR1 ↓ MRP1↓ Drug resistance to doxorubicin ↓ Apoptosis ↑ |
| Pouyafar et al. (2019) | Cancer stem cells of human adenocarcinoma cell line HT-29 | Sulindac |
Transcription of autophagy signaling genes: (GALNT11) ↑ in cancer stem cells Trans-differentiation ↑ Decreased cell resistance ↓ |
| Hoca et al. (2020) | PANC-1 derived CD133+ and CD133- pancreatic cancer cells | Quercetin |
At 5,10,25,50 and 100 μM concentrations of combined treatment of CD133+ cells resulted: ACTA-2, IL-1β, and N-Cadherin ↓ TNF-α and Vimentin ↑ TNF-α and N-Cadherin ↓ in RSV alone treated CD133+ cells Quercetin could prevent EMT to a greater extent than RSV |
| Shin et al. (2020) | HeLa cervical cancer adherent and stem-like cells | Pterostilbene |
Pterostilbene exhibited better effects than RSV including: Cell cycle arrest at G2/M phase ROS-mediated Caspase-dependent apoptosis ↑ MMP-2/9 expression ↓ Tumor sphere formation and migration abilities ↓ Stemness marker expression: CD133, Oct-4, Sox2, and Nanog ↓ STAT-3 ↓ |