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. 2020 Dec 4;10:21273. doi: 10.1038/s41598-020-78087-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of collagen in MCF7/MCR5 co-culture spheroids treated and non-treated with RT or TGF-β. (a) Scheme of the experiment. (b) Typical cryosections of T10 and T10F30 spheroids stained with Picro Sirius Red. Scale bars: 50 µm. (c) Cumulative quantitative analyses of collagen expression (Picro Sirius Red) in cryosections from (blue bar) monoculture T10 and (green bar) co-culture T10F30 spheroids. Data presented as mean ± SD [n = 3–10; *p < 0.05; ***p < 0.001 compared to monoculture spheroids, using two-sample t-test; ^##p < 0.01 compared to control (no treatment) co-culture spheroids using ANOVA].