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. 2020 Dec 4;11:6224. doi: 10.1038/s41467-020-20010-9

Fig. 3. Expression levels of RME1 and its targets are related to the capacity to form chlamydospores in C. albicans strains.

Fig. 3

a Clinical isolates of C. albicans exhibit differences in chlamydospore formation efficiency. The upper panel shows strains that formed masses of chlamydospores when grown in liquid PCB at 25 °C for 24 h, whilst the bottom panel shows strains defective for chlamydospore formation under the tested conditions. WT SC5314 strain was used as reference for comparison. Scale bar =  10 μm. b Expression levels of RME1 (P = 0.000022; 0.001395; 0.000035; 0.00062; 0.058885; 0.083474; 0.275589), CSP1 (P = 0.000074; <0.000001; 0.000126; 0.000357; 0.71581; 0.156621; 0.221736), CSP2 (P = 0.000797; 0.000078; 0.000163; 0.000001; 0.848682; 0.388113; 0.130289), ORF19.654 (P = 0.000047; 0.000104; <0.000001; 0.00062; 0.000517; 0.000496; 0.000658), PGA55 (P = 0.000905; 0.000443; 0.005717; 0.000285; 0.092887; 0.52506; 0.330046) and MAC1 (control) were quantified by RT-qPCR in C. albicans strains and normalized against SC5314 values. Data are expressed as the mean ± SD, n = 3 biological replicates, over three experiments. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.