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. 2020 Dec 4;10:21280. doi: 10.1038/s41598-020-77978-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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BR103354 acutely reduces blood glucose levels via FAP inhibition in ob/ob mice. 8-week-old ob/ob mice (n = 5–9/group) were treated with BR103354 or vehicle before 15 min i.p. treatment of hFGF21. Blood was collected at the indicated time points. (a) Nonfasting blood glucose levels were measured at the indicated time points. AUC values are shown for comparison between treatment groups. (b) Plasma FAP activity was measured by fluorometric assay using AMC substrate. (c) Plasma intact hFGF21 levels were measured using ELISA kit at 1, 3, 6, and 9 h. All data are the means ± S.D. *P < 0.05, **P < 0.01 and *** P < 0.001 vs. vehicle group.