Table 3.

In vivo PK profiles of BR103354.

Species	Parameters	Results
Mouse	Tmax (h, 1/5/10/100/200 mg/kg)	0.5/0.5/0.5/1/1
	Cmax (µg/mL, 1/5/10/100/200 mg/kg)	2.3/7.2/19.2/66.0/122.5
	T1/2 (h, 1/5/10/100/200 mg/kg)	1.2/1.1/1.2/4.0/3.8
	AUC(0–6 h) (µg·h/mL, 1/5/10/100/200 mg/kg)	3.7/10.8/41.1/17.0/29.2
	Bioavailability (%)	48.4
Rat	Tmax (h, 10 mg/kg)	1.1
	Cmax (µg/mL, 10 mg/kg)	4.4
	T1/2 (h, 10 mg/kg)	3.5
	AUC(0–6 h) (µg·h/mL, 10 mg/kg)	19.7
Monkey	Tmax (h, 10/30 mg/kg)	2.3/2.3
	Cmax (µg/mL, 10/30 mg/kg)	0.42/2.0
	T1/2 (h, 10/30 mg/kg)	1.3/2.8
	AUC(0–6 h) (µg·h/mL, 10/30 mg/kg)	1.2/6.4