Figure 2:

The implication of ECM-based research in developing regenerative medicine for muscle-tendon interface. Knowledge regarding the composition and role of the ECM at the muscle-tendon interface will be advanced using techniques such as mass spectrometry, protein labeling and 3D imaging. This information will provide critical design information for developing ECM instructive scaffolds, which can be used alone or in combination with cells and growth factors. It is hypothesized that regenerative medicine strategies that involve the use of ECM instructive scaffolds will facilitate scar-free repair at the muscle-tendon interface.