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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Cancer Prev Res (Phila). 2020 Sep 11;13(12):979–988. doi: 10.1158/1940-6207.CAPR-20-0186

Figure 1. EZH2 expression and activity is increased in mouse HG-PIN and maintained during prostate cancer initiation and progression.

Figure 1.

(A) Gene set enrichment analysis (GSEA) shows that EHZ2 and/or H3K27me3 associated molecular signatures are positively enriched in Hi-MYC murine PCa tumors when compared to wild-type prostate tissue. * p<0.05. (B) Representative H&E and IHC images from indicated mouse genotypes at 5 months of age (HG-PIN). It is observed that EZH2 and H3K27me3 is increased in PCa mouse models compared to age matched wild-type controls. (C) IHC images and quantitation from Hi-MYC mice indicating H3K27me3 positivity remains significantly elevated during HG-PIN through progression to PCa. For B-C, a total of 5 mice/genotype were analyzed. Scale bar = 50μm.