TABLE 3:

Randomized Placebo-Controlled Trials in Pediatric Anxiety Disorders

Class	Reference	Disorder	N	Results
5-HT1A modulator	Strawn et al, 2017	GAD	227	Buspirone = placebo
	Strawn et al, 2017	GAD	341	Buspirone = placebo
SSRI	RUPP, 2001	Mixed anxiety disorders	124	Fluvoxamine > placebo
	Strawn et al, 2019	GAD	51	Escitalopram > placebo
	Rynn et al, 2001	GAD	22	Sertraline > placebo
	Black and Uhde, 1994	Selective mutism, SoAD, Avoidant Disorder	15	Fluoxetine > placebo
	Wagner et al, 2004	SoAD	322	Paroxetine > placebo
	Beidel et al, 200*	SoAD	122	SET-C > fluoxetine > placebo
	Walkup et al, 2008	Mixed anxiety disorders	488	CBT = sertraline > placebo CBT+sertraline > sertraline/ CBT CBT+sertraline > placebo
	Birmaher et al, 2003	Mixed anxiety disorders	74	Fluoxetine > placebo
SNRI	Rynn et al, 2007	GAD	153 160	Venlafaxine ER > placebo
	Strawn et al, 2015	GAD	272	Duloxetine > placebo
	March et al, 200*	SoAD	293	Venlafaxine > placebo
	Geller et al, 2007	Mixed anxiety disorders + ADHD	176	Atomoxetine > placebo
TCA	Gittleman-Klein & Klein, 1971	SoAD and mixed anxiety	35	Imipramine > placebo
	Berney et al, 1981	School refusal	51	Clomipramine = placebo
	Klein et al, 1992	Separation anxiety with or without school avoidance	21	Imipramine = placebo
BZD	Bernstein et al, 1990	School refusal and Separation Anxiety Disorder	24	Alprazolam = imipramine = placebo
	Simeon et al, 1992	Overanxious Disorder and Avoidant Disorder	30	Alprazolam = placebo
	Grae et al, 1994	Separation Anxiety Disorder	15	Clonazepam = placebo
α2 agonist	Strawn et al, 2017	Mixed anxiety disorders	83	Guanfacine = placebo for PARS Guanfacine > placebo for CGI-I.

Abbreviations: SSRI- Selective Serotonin Reuptake Inhibitor; SNRI- Serotonin Norepinephrine Reuptake Inhibitor; BZD- Benzodiazepine; TCA, tricyclic antidepressant; PARS, pediatric anxiety rating scale, CGI-I, clinical global impression-improvement; SoAD, social anxiety disorder; SET-C- Social Effectiveness Therapy for Children; CBT- Cognitive Behavioral Therapy; CGI-S- Clinical Global Impression-Severity Scale; ADHD- Attention Deficit Hyperactive Disorder; GAD – Generalized Anxiety Disorder