Table 2.

Most common solvents employed as oil phase for the preparation of PLGA MPs

Solvents	Non-halogenated	Halogenated	References
Dichloromethane		X	Çetin Altındal and Gümüşderelioğlu (2019), Cocks et al. (2015)
Chloroform		X	Wise (2000)
Tetrahydrofuran	X		Tang et al. (2012)
Hexafluoro-isopropanol		X	da Silva-Junior et al. (2009)
Ethanol	X		Yang et al. (2007)
Isosorbide dimethyl ether	X		Haji Mansor et al. (2018)
N-Methylpyrrolidone	X		Bilati et al. (2005)
Ethyl acetate	X		Gentile et al. (2016), Li et al. (2018)
DMSO	X		Choi and Park (2006)
Glycofurol	X		Allhenn and Lamprecht (2011)
Acetone	X		Herrmann (1995)
Methyl ethyl ketone	X		Sah et al. (1996)
Propylene carbonate	X		Grizić and Lamprecht (2018)
Ethyl propionate	X		Kang et al. (2014)
Ethyl formate	X		Sah (2000)
Dioxane	X		Wang et al. (2017)
Methyl chloride		X	Klose et al. (2006)
Dimethyl carbonate	X		Esposito et al. (2016)
Acetonitrile	X		Morales-Cruz et al. (2012), Rodriguez de Anda et al. (2019)