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. Author manuscript; available in PMC: 2021 Apr 9.
Published in final edited form as: Oncogene. 2020 Oct 9;39(49):7209–7223. doi: 10.1038/s41388-020-01493-8

Fig. 3. Predominant differential expression of microRNA isoforms (iso-miRs) is associated with neuroendocrine differentiation in CRPC.

Fig. 3.

A. Heat map showing differentially expressed iso-miRs between CRPC-adeno cases (n=25; clinical tissues, n=21 + PDX models AdLuCaP-70, −78, −81) as compared to CRPC-NE (n=10; clinical tissues, n=6 + PDX models LuCaP-49, −145.1, −145.2 + NCI-H660 cell line).

B. miRNA loci producing ≥5 differentially expressed iso-miRs plotted as a function of number of observed iso-miRs.

C. ROC curve analyses showing the ability of ‘miRNA classifier including iso-miRs’ to distinguish between class 0 (CRPC-Adeno) and class 1 (CRPC-NE).