Table 1:
Association of HIV Specific Characteristics and Elevated Biomarkers.
| sCD14† OR (95%CI) |
sCD163† OR (95%CI) |
I-FABP† OR (95%CI) |
sVCAM-1† OR (95%CI) |
sICAM-1†
OR (95%CI) |
|
|---|---|---|---|---|---|
| Stratified by HIV status and current CD4 count (cells/mm3) | |||||
| HIV- | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| HIV+, CD4 ≥500 | 7.87 (4.36 - 12.22) | 7.70 (1.56 - 5.38) | 2.21 (1.31 - 3.77) | 2.34 (1.24 - 3.14) | 3.86 (2.25 - 6.63) |
| HIV+, 200> CD4 <500 | 8.79 (4.66 - 15.59) | 2.39 (1.10 - 5.21) | 3.43 (1.95 - 6.02) | 1.73 (1.17 - 3.08) | 3.54 (1.94 - 6.45) |
| HIV+, CD4 ≤200 | 9.32 (3.49 - 22.85) | 2.49 (1.11 - 5.88) | 4.59 (1.80 - 11.72) | 2.36 (1.05 - 6.10) | 3.61 (1.33 - 9.74) |
| Stratified by HIV status and viral load (copies/mL) | |||||
| HIV- | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| HIV+,VL <50 | 7.61 (3.06 - 15.95) | 2.40 (1.28 - 4.55) | 2.71 (1.76 - 4.35) | 1.91 (1.21 - 3.02) | 3.65 (2.22 - 5.99) |
| HIV+, VL ≥50 | 8.61 (4.94 - 14.99) | 4.88 (1.71 - 9.97) | 3.26 (1.38 - 7.69) | 3.97 (1.71 - 9.19) | 5.29 (2.20 - 12.67) |
| Stratified by HIV status and ART duration (years) | |||||
| HIV- | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| HIV+, ART <4 | 8.35 (4.77 - 18.33) | 3.53 (1.73 - 5.88) | 3.74 (2.04 - 6.87) | 3.10 (1.71 - 5.62) | 4.42 (2.36- 8.28) |
| HIV+, ART 4-10 | 7.83 (4.23- 13.65) | 2.83 (1.42 - 4.93) | 2.91 (1.67- 5.06) | 1.05 (0.88 - 2.70) | 1.01 (0.78- 3.26) |
| HIV+, ART >10 | 7.29 (3.92 - 12.52) | 1.81 (1.33 - 4.01) | 2.61 (1.48 - 4.59) | 1.02 (0.82 - 2.56) | 1.08 (0.79- 3.48) |
OR, Odds Ratio; CI, confidence interval. ART, antiretroviral therapy; and VL, viral load. Other abbreviations as in Table 1
†
Model are adjusted for age, dyslipidemia, BMI, hypertension, diabetes, smoking status.