Table 1.
The clinicopathological characteristics of the cHCC-CCA, HCC, and iCCA cases. HBsAg hepatitis B surface antigen, HCV-Ab hepatitis C virus antibody, AFP alpha-fetoprotein, DCP des-gamma-carboxy prothrombin, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, AR anatomical resection, NAR non-anatomical resection, NS not significant. Numbers are described as the mean ± standard deviation. Values in parentheses are percentages
| cHCC-CCA (n = 19) | HCC (n = 742) | iCCA (n = 121) | Statistical analysis | |
|---|---|---|---|---|
| Sex |
Male: 12 Female: 7 |
Male: 583 Female: 159 |
Male: 72 Female: 49 |
p < 0.0001 |
| Age | 64.1 ± 10.6 | 66.7 ± 9.7 | 66.7 ± 10.0 | NS |
| Platelet number (× 104/μL) | 17.2 ± 10.7 | 13.6 ± 7.8 | 19.1 ± 9.0 | HCC vs. iCCA: p < 0.0001 |
| Total bilirubin (mg/dL) | 1.19 ± 0.71 | 1.05 ± 1.21 | 0.89 ± 0.72 | NS |
| Albumin (g/dL) | 3.91 ± 0.50 | 3.82 ± 0.54 | 3.99 ± 0.47 | HCC vs. iCCA: p = 0.0032 |
| Prothrombin time (%) | 83.6 ± 12.0 | 83.7 ± 15.7 | 91.6 ± 16.0 | HCC vs. iCCA: p < 0.0001 |
| HBsAg |
Positive: 3 (15.8%) Negative: 16 (84.2%) Missing data: 0 |
Positive: 147 (19.8%) Negative: 588 (79.2%) Missing data: 7 |
Positive: 7 (5.8%) Negative: 109 (90.1%) Missing data: 5 |
p < 0.0001 |
| HCV-Ab |
Positive: 8 (42.1%) Negative: 11 (57.9%) Missing data: 0 |
Positive: 336 (45.3%) Negative: 400 (53.9%) Missing data: 6 |
Positive: 16 (13.2%) Negative: 102 (84.3%) Missing data: 3 |
p < 0.0001 |
| AFP (ng/mL) | 110.7 ± 343.5 | 7416 ± 108118.1 | 12.6 ± 49.3 | NS |
| DCP (mAU/mL) | 1613.3 ± 5099.2 | 7895.5 ± 35673.2 | 693.1 ± 3890.6 | NS |
| CEA (ng/mL) | 2.88 ± 3.01 | 3.65 ± 2.61 | 7.36 ± 18.9 | HCC vs. iCCA: p = 0.0015 |
| CA19-9 (U/mL) | 37.2 ± 31.6 | 48.3 ± 55.1 | 308.7 ± 760.4 |
HCC vs. iCCA: p < 0.0001 cHCC-CCA vs. iCCA: p = 0.0294 |
| Tumor number | 1.21 ± 0.42 | 1.68 ± 1.56 | 1.48 ± 1.70 | NS |
| Tumor size (cm) | 4.07 ± 2.39 | 4.68 ± 4.19 | 4.63 ± 2.75 | NS |
| Major portal vein invasion |
Presence: 3 (15.8%) Absence: 16 (84.2%) Missing data: 0 |
Presence: 67 (9.0%) Absence: 618 (83.3%) Missing data: 57 |
Presence: 14 (11.6%) Absence: 94 (77.7%) Missing data: 13 |
NS |
| Major hepatic vein invasion |
Presence: 0 (0%) Absence: 19 (100%) Missing data: 0 |
Presence: 25 (3.4%) Absence: 658 (88.7%) Missing data: 59 |
Presence: 9 (7.4%) Absence: 99 (81.8%) Missing data: 13 |
NS |
| Major biliary tract invasion |
Presence: 7 (36.8%) Absence: 12 (63.2%) Missing data: 0 |
Presence: 37 (5.0%) Absence: 646 (87.1%) Missing data: 59 |
Presence: 22 (18.2%) Absence: 80 (66.1%) Missing data: 19 |
p < 0.0001 |
| Surgical procedure |
AR: 13 (68.4%) NAR: 6 (31.6%) |
AR: 471 (63.5%) NAR: 271 (36.5%) |
AR: 95 (78.5%) NAR: 26 (21.5%) |
p = 0.0053 |
| Resection of extrahepatic bile duct |
Presence: 1 (5.3%) Absence: 18 (94.7%) |
Presence: 3 (0.4%) Absence: 739 (99.6%) |
Presence: 29 (24.0%) Absence: 92 (76.0%) |
p < 0.0001 |
| Lymph node dissection |
Presence: 1 (5.3%) Absence: 18 (94.7%) |
Presence: 9 (1.2%) Absence: 733 (98.8%) |
Presence: 93 (76.9%) Absence: 28 (23.1%) |
p < 0.0001 |