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. 2020 Dec 4;12:161. doi: 10.1186/s13195-020-00724-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Optical coherence tomography angiography (OCTA) images of the superficial (a–c) and deep (g–i) capillary plexuses were extracted from the OCTA machines. d–f, j–l Vessel density maps of the macular annulus region showing retinal microvasculature of participants with Alzheimer’s disease (AD; d, j), mild cognitive impairment (MCI; e, k), and controls (f, l). AD participants showed a decrease in vessel densities in both plexuses compared to controls. MCI participants showed a decrease vessel density only in superficial capillary plexus and not the deep capillary plexus