Table 2.
Multivariate analysis of vessel density and fractal dimension with cognitive impairment
| Cognitive status | Superficial capillary plexus | Deep capillary plexus | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | β | 95 CI | P value* | Mean ± SD | β | 95 CI | P value* | |
| Vessel density (%) | ||||||||
| Control | 15.66 ± 0.96 | Reference | 21.54 ± 1.55 | Reference | ||||
| MCI | 14.94 ± 1.02 | − 0.72 | − 1.22 to − 0.21 | 0.006 | 20.81 ± 1.65 | − 0.73 | − 1.54 to 0.09 | 0.081 |
| AD | 14.78 ± 1.14 | − 0.88 | − 1.49 to − 0.26 | 0.006 | 20.42 ± 1.60 | − 1.12 | − 2.00 to − 0.21 | 0.015 |
| Fractal dimension | ||||||||
| Control | 1.861 ± 0.010 | Reference | 1.879 ± 0.013 | Reference | ||||
| MCI | 1.850 ± 0.011 | − 0.011 | − 0.016 to − 0.006 | < 0.001 | 1.876 ± 0.014 | − 0.003 | − 0.010 to 0.004 | 0.386 |
| AD | 1.853 ± 0.011 | − 0.008 | − 0.014 to − 0.002 | 0.006 | 1.876 ± 0.014 | − 0.004 | − 0.011 to 0.004 | 0.371 |
AD Alzheimer’s disease, CI confidence intervals, MCI mild cognitive impairment, SD standard deviation
*Adjusted for age, gender, race, diabetes, blood pressure (systolic and diastolic levels), and signal strength of OCTA scans