Table 3.
Multivariate analysis of perfusion density of large vessels and foveal avascular zone with cognitive impairment
| Cognitive status | Superficial capillary plexus | Deep capillary plexus | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | β | 95 CI | P value* | Mean ± SD | β | 95 CI | P value* | |
| Perfusion density of large vessels (%) | ||||||||
| Control | 6.92 ± 1.16 | Reference | – | – | ||||
| MCI | 6.39 ± 1.27 | − 0.53 | − 1.15 to 0.09 | 0.091 | – | – | – | – |
| AD | 7.02 ± 1.29 | 0.10 | − 0.61 to 0.81 | 0.787 | – | – | – | – |
| Foveal avascular zone area (mm2) | ||||||||
| Control | 0.31 ± 0.12 | Reference | 1.11 ± 0.47 | Reference | ||||
| MCI | 0.35 ± 0.12 | 0.041 | − 0.02 to 0.10 | 0.190 | 1.24 ± 0.39 | 0.129 | − 0.07 to 0.33 | 0.197 |
| AD | 0.34 ± 0.14 | 0.034 | − 0.04 to 0.11 | 0.380 | 1.13 ± 0.43 | 0.016 | − 0.23 to 0.26 | 0.898 |
AD Alzheimer’s disease, CI confidence intervals, MCI mild cognitive impairment, SD standard deviation
*Adjusted for age, gender, race, diabetes, blood pressure (systolic and diastolic levels), and signal strength of OCTA scans