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. 2020 Dec 5;39:273. doi: 10.1186/s13046-020-01722-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The expression levels of MUC18 in cancers have clinical significance. a The copy numbers of MUC18 mRNA were analyzed across a variety of cancers (red color) and normal tissues (black color) in TCGA cohort studies. The MUC18 gene expression was elevated in melanoma (SKCM) and renal cell carcinoma (KIRC). b The MUC18 gene expression level in melanoma (SKCM) was five times as much as that in normal lung and prostate tissues. c IHC of normal tissue microarray with JM1-24-3, showed positive staining on smooth muscle cells in small vessels of kidney, lung and skin, but not on vessels larger than small capillaries, while other normal tissues were negative. d MUC18 IHC images with JM1-24-3 showing variable staining intensity from negative (upper left panel) to strong positive (lower right panel) on melanoma patient tissue slides. e Staining intensity correlation of eight melanoma patients showed that metastatic melanoma patients had higher intensity staining of MUC18 with JM1-24-3 mAb. Also, all metastatic patients (5/5) showed stronger intensity