TABLE 2.
Adjusted associations between visuospatial scores and MRI‐derived measures of cortical thickness for selected brain regions a
| Group and measure | Superior temporal gyrus | Inferior parietal | Inferior temporal gyrus | Inferior frontal gyrus | Fusiform | Lingual gyrus | Lateral occipital | Pericalcarine |
|---|---|---|---|---|---|---|---|---|
| MCI | ||||||||
| ADNI1 | ||||||||
| ADNI‐VS | 3.66 | 4.15 | 4.77 | 3.27 | 3.85 | 2.45 | 3.04 | 2.14 |
| Z‐score | 3.76 | 3.97 | 4.58 | 3.15 | 3.77 | 2.43 | 3.05 | 1.78 |
| Clock Score | 3.43 | 3.15 | 4.17 | 2.94 | 2.97 | 1.38 | 2.09 | 1.58 |
| ADNI 2/GO | ||||||||
| ADNI‐VS | 2.50 | 2.25 | 1.26 | 1.72 | 2.03 | 1.01 | 1.99 | −0.85 |
| Z‐score | 2.56 | 2.62 | 1.18 | 1.93 | 1.85 | 1.36 | 2.11 | −0.41 |
| Clock score | 2.72 | 1.59 | 1.41 | 2.12 | 2.19 | 0.56 | 0.84 | −1.41 |
| AD | ||||||||
| ADNI 1 | ||||||||
| ADNI‐VS | 2.07 | 4.45 | 1.89 | 2.61 | 2.49 | 1.30 | 3.79 | 1.37 |
| Z‐score | 2.80 | 6.27 | 2.96 | 3.00 | 4.40 | 3.42 | 6.09 | 2.67 |
| Clock score | 2.02 | 5.61 | 2.41 | 2.26 | 3.60 | 3.53 | 5.59 | 1.76 |
| ADNI 2/GO | ||||||||
| ADNI‐VS | 0.37 | 4.42 | 2.03 | 0.20 | 3.48 | 2.68 | 4.05 | 1.37 |
| Z‐score | 1.60 | 6.63 | 3.06 | 0.09 | 5.58 | 4.29 | 6.50 | 2.49 |
| Clock score | 1.25 | 5.54 | 3.02 | 1.44 | 4.11 | 1.43 | 4.25 | 1.30 |
a
Test statistics for MRI cortical thickness measures (adjusted for intracranial volume) from regression models for the visuospatial outcomes controlling for age, education, sex, presence of ≥1 APOE‐ε4 alleles, by baseline diagnosis and ADNI phase. Bolded values indicate P values < 0.05.
Abbreviations: AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; ADNI‐VS, ADNI visuospatial composite; LCD, least common denominator; MCI, mild cognitive impairment; MRI, magnetic resonance imaging.