TABLE 3.
Baseline demographic, clinical data by baseline diagnosis
| Normal Cognition (NC) | |||
|---|---|---|---|
| ADNI1 n = 229 | ADNI2/GO n = 401 | ADNI3 n = 334 | |
| Baseline demographic characteristics | |||
| Female, n (%) | 110 (48%) | 226 (56%) | 203 (61%) |
| Age in years, mean (SD) | 76.0 (5.0) | 72.8 (6.1) | 70.8 (5.8) |
| Education in years, mean (SD) | 16.1 (2.9) | 16.6 (2.6) | 16.9 (2.2) |
| ≥1 APOE‐ε4 allele, n (%) | 61 (27%) | 87 (30%) | 86 (26%) |
| Baseline language data, mean (SD) | |||
| ADNI‐Lan | 0.80 (0.71) | 0.71 (0.66) | 0.80 (0.73) |
| LCD z‐score a | −0.06 (0.61) | −0.03 (0.64) | 0.08 (0.60) |
| WS z‐score | 0.05 (0.54) | 0.03 (0.55) | −0.004 (0.56) |
| MMSE Language Items | 7.84 (0.42) | 7.82 (0.43) | 7.83 (0.41) |
| ADAS‐Cog Language Items | 14.80 (0.53) | 14.77 (0.57) | 14.84 (0.45) |
| Category Fluency – Animals | 19.93 (5.59) | 20.93 (5.29) | 22.00 (5.63) |
| Category Fluency – Vegetables | 14.70 (3.91) | NA | NA |
| Boston Naming (Total) | 27.89 (2.29) | 28.22 (2.10) | NA |
| MoCA – Animal Naming | NA | 2.90 (0.30) | 2.93 (0.27) |
| MoCA – All Language Items | NA | 5.44 (0.74) | 5.52 (0.75) |
| Baseline Visuospatial data, mean (SD) | |||
| ADNI‐VS | 0.27 (0.62) | 0.20 (0.56) | 0.20 (0.60) |
| Z‐score | 0.03 (0.97) | 0.01 (0.93) | −0.04 (1.09) |
| Clock score | 4.86 (0.42) | 4.87 (0.37) | 4.85 (0.41) |
| Mild Cognitive Impairment (MCI) | |||
|---|---|---|---|
| ADNI1 n = 385 | ADNI2/GO n = 546 | ADNI3 n = 102 | |
| Baseline Demographic Characteristics | |||
| Female, n (%) | 136 (35%) | 241 (44%) | 38 (37%) |
| Age in years, mean (SD) | 75.5 (6.8) | 72.8 (6.9) | 73.5 (7.3) |
| Education in years, mean (SD) | 15.6 (3.0) | 16.2 (2.7) | 16.6 (2.5) |
| ≥1 APOE‐ε4 allele, n (%) | 209 (54%) | 210 (48%) | 28 (27%) |
| Baseline language data, mean (SD) | |||
| ADNI‐Lan | −0.04 (0.76) | 0.34 (0.71) | 0.24 (0.57) |
| LCD z‐score a | −0.71 (0.89) | −0.42 (0.78) | −0.35 (0.63) |
| WS z‐score | −0.95 (1.18) | −0.39 (0.87) | −0.51 (0.59) |
| MMSE Language Items | 7.65 (0.56) | 7.66 (0.59) | 7.70 (0.52) |
| ADAS‐Cog Language Items | 14.41 (0.86) | 14.60 (0.72) | 14.67 (0.54) |
| Category Fluency – Animals | 15.82 (4.92) | 18.01 (5.19) | 17.52 (4.34) |
| Category Fluency – Vegetables | 10.71 (3.45) | NA | NA |
| Boston Naming (Total) | 25.47 (4.10) | 26.75 (3.45) | NA |
| MoCA – Animal Naming | NA | 2.82 (0.43) | 2.74 (0.48) |
| MoCA – All Language Items | NA | 5.19 (0.97) | 4.87 (1.02) |
| Baseline visuospatial data, mean (SD) | |||
| ADNI‐VS | −0.10 (0.80) | 0.01 (0.69) | −0.01 (0.68) |
| Z‐score | −0.59 (1.44) | −0.35 (1.18) | −0.39 (1.33) |
| Clock score | 4.64 (0.68) | 4.72 (0.56) | 4.71 (0.58) |
| Baseline demographic characteristics | |||
| Female, n (%) | 85 (46%) | 72 (41%) | 12 (40%) |
| Age in years, mean (SD) | 76.1 (6.7) | 75.6 (7.4) | 75.2 (8.7) |
| Education in years, mean (SD) | 14.7 (3.1) | 15.8 (2.8) | 15.9 (3.1) |
| ≥1 APOE‐ε4 allele, n (%) | 123 (66%) | 94 (67%) | 7 (23%) |
| Baseline language data, mean (SD) | |||
| ADNI‐Lan | −0.75 (0.87) | −0.59 (0.99) | −0.24 (0.87) |
| LCD z‐score a | −1.48 (1.39) | −1.58 (1.55) | −1.31 (1.06) |
| WS z‐score | −2.12 (1.86) | −1.80 (1.41) | −1.21 (0.97) |
| MMSE Language Items | 7.51 (0.71) | 7.48 (0.88) | 7.30 (1.06) |
| ADAS‐Cog Language Items | 13.70 (1.49) | 13.59 (1.70) | 14.06 (0.93) |
| Category Fluency – Animals | 12.38 (4.91) | 12.14 (5.13) | 12.87 (5.60) |
| Category Fluency – Vegetables | 7.81 (3.34) | NA | NA |
| Boston Naming (Total) | 22.21 (6.26) | 21.91 (5.95) | NA |
| MoCA – Animal Naming | NA | 2.42 (0.81) | 2.81 (0.40) |
| MoCA – All Language Items | NA | 4.17 (1.53) | 4.56 (1.31) |
| Baseline visuospatial data, mean (SD) | |||
| ADNI‐VS | −0.59 (0.93) | −0.38 (0.87) | −0.46 (0.88) |
| Z‐score | −1.68 (2.18) | −1.38 (2.07) | −1.57 (2.26) |
| Clock score | 4.34 (0.98) | 4.44 (0.91) | 4.20 (1.15) |
a
LCD, “least common denominator” z score strategy; WS, “wave specific” z score strategy; see text for details.
Abbreviations: ADAS, Alzheimer's Disease Assessment Schedule; ADAS‐Cog, Alzheimer's Disease Assessment Schedule–Cognition; ADNI, Alzheimer's Disease Neuroimaging Initiative; ADNI‐Lan, ADNI language composite; ADNI‐VS, ADNI visuospatial composite; APOE, apolipoprotein E; LCD, least common denominator; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; MRI, magnetic resonance imaging; SD, standard deviation; WS, wave specific.