TABLE 5.
Association between composite scores and comparator scores with risk of conversion a
| Language scores by phase | NC to MCI (95% CI) | MCI to AD (95% CI) |
|---|---|---|
| All | 107 conversions /509 enrolled | 320 conversions / 799 enrolled |
| ADNI‐Lan | 0.84 (0.69, 1.04) | 0.75 (0.66, 0.84) |
| LCD z‐score | 0.76 (0.64, 0.90) | 0.90 (0.80, 1.01) |
| WS z‐score | 0.80 (0.69, 0.94) | 0.82 (0.73, 0.92) |
| Category Fluency – Animals | 0.88 (0.71, 1.08) | 0.76 (0.68, 0.86) |
| MMSE Language Items | 0.83 (0.72, 0.97) | 1.06 (0.95, 1.18) |
| ADAS‐Cog Language Items | 0.83 (0.72, 0.95) | 0.91 (0.81, 1.01) |
| ADNI1 only | 62 conversions / 222 enrolled | 206 conversions / 373 enrolled |
| ADNI‐Lan | 0.87 (0.63, 1.19) | 0.79 (0.69, 0.90) |
| LCD z‐score | 0.64 (0.48, 0.87) | 0.98 (0.84, 1.14) |
| WS z‐score | 0.71 (0.54, 0.93) | 0.86 (0.74, 0.99) |
| Category Fluency – Vegetables | 0.91 (0.67, 1.23) | 0.79 (0.69, 0.90) |
| ADNI1, 2, GO only | 107 conversions / 508 enrolled | 320 conversions / 795 enrolled |
| ADNI‐Lan | 0.84 (0.69, 1.04) | 0.75 (0.66, 0.84) |
| LCD z‐score | 0.76 (0.64, 0.90) | 0.90 (0.80, 1.01) |
| WS z‐score | 0.80 (0.69, 0.94) | 0.82 (0.73, 0.92) |
| Boston Naming (Total) | 0.95 (0.83, 1.09) | 0.79 (0.69, 0.90) |
| ADNI2, GO, 3 only | 45 conversions / 287 enrolled | 114 conversions / 426 enrolled |
| ADNI‐Lan | 0.95 (0.75, 1.21) | 0.65 (0.50, 0.85) |
| LCD z‐score | 0.97 (0.77, 1.23) | 0.81 (0.67, 0.97) |
| WS z‐score | 1.01 (0.81, 1.24) | 0.76 (0.61, 0.96) |
| MoCA – Animal Naming | 0.91 (0.70, 1.19) | 0.78 (0.66, 0.92) |
| MoCA – All Language Items | 1.05 (0.83, 1.32) | 0.80 (0.64, 0.99) |
| Visuospatial scores across all phases |
NC to MCI (95% CI) 107 conversions/509 enrolled |
MCI to AD (95% CI) 320 conversions / 799 enrolled |
| ADNI‐VS | 0.90 (0.74, 1.09) | 0.82 (0.72, 0.92) |
| Z‐score | 0.91 (0.75, 1.09) | 0.78 (0.68, 0.90) |
| Clock score | 0.98 (0.85, 1.14) | 0.80 (0.70, 0.91) |
The top row in each section provides the number of people who converted and the total number of people at the beginning of that phase of the study. Numbers in subsequent rows represent the adjusted time ratio (95% confidence interval) associated with a one SD higher score for each measure. For example, the top left entry indicates that compared to people who scored at the mean for ADNI‐Lan, people who scored one SD above the mean had an adjusted time ratio of 0.84 (95% confidence interval 0.69‐1.04).
Abbreviations: AD, Alzheimer's disease; ADAS, Alzheimer's Disease Assessment Schedule; ADAS‐Cog, Alzheimer's Disease Assessment Schedule–Cognition; ADNI, Alzheimer's Disease Neuroimaging Initiative; ADNI‐Lan, ADNI language composite; ADNI‐VS, ADNI visuospatial composite; APOE, apolipoprotein E; LCD, least common denominator; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; MRI, magnetic resonance imaging; NC, normal cognition; WS, wave specific.