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Loss of Pdcd2l causes embryonic death in mice. A) Litter sizes of wildtype and heterozygous matings. B) Embryo resorptions in mouse uteri from heterozygous Pdcd2l matings, at embryonic days [E] 12.5 and 17.5. Arrows point to embryo resorptions and in the bottom panel indicate a small embryo that was genotyped as a knockout. C) Analysis of genotype ratios from heterozygous matings in comparison to the anticipated Mendelian inheritance of 1:2:1 wildtype:heterozygous:knockout pups.
