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. 2020 Dec 2;8:e10386. doi: 10.7717/peerj.10386

Table 2. GO analysis of different expressed genes in CESC.

Expression Category Term Count % p-Value FDR
Up-regulated GOTERM_MF_DIRECT GO:0005524∼ATP binding 10 21.03 2.84E−4 0.270953
GOTERM_MF_DIRECT GO:0003678∼DNA helicase activity 2 4.21 0.012333 11.169161
GOTERM_MF_DIRECT GO:0003688∼DNA replication origin binding 2 4.21 0.018445 16.278756
GOTERM_MF_DIRECT GO:0003682∼chromatin binding 4 8.41 0.021525 18.752384
GOTERM_CC_DIRECT GO:0030496∼midbody 6 12.62 2.68E−7 2.65E−4
GOTERM_CC_DIRECT GO:0005737∼cytoplasm 14 29.44 1.50E−4 0.147574
GOTERM_CC_DIRECT GO:0005876∼spindle microtubule 3 6.31 0.001486 1.457975
GOTERM_CC_DIRECT GO:0005654∼nucleoplasm 8 16.82 0.005554 5.351061
GOTERM_CC_DIRECT GO:0000784∼nuclear chromosome, telomeric region 3 6.31 0.063091 9.946422
GOTERM_CC_DIRECT GO:0072687∼meiotic spindle 2 4.21 0.014282 13.241928
GOTERM_CC_DIRECT GO:0042555∼MCM complex 2 4.21 0.014282 13.241928
GOTERM_CC_DIRECT GO:0005680∼anaphase-promoting complex 2 4.21 0.035339 29.901598
GOTERM_CC_DIRECT GO:0005634∼nucleus 9 18.93 0.049470 39.406713
GOTERM_CC_DIRECT GO:0072686∼mitotic spindle 2 4.21 0.054262 42.356169
GOTERM_CC_DIRECT GO:0005819∼spindle 2 4.21 0.062745 47.263108
GOTERM_CC_DIRECT GO:0000776∼kinetochore 2 4.21 0.092682 61.726231
GOTERM_BP_DIRECT GO:0000910∼cytokinesis 3 6.31 9.78E−4 1.154575
GOTERM_BP_DIRECT GO:0044772∼mitotic cell cycle phase transition 2 4.21 0.007770 8.844187
GOTERM_BP_DIRECT GO:0051988∼regulation of attachment of spindle microtubules to kinetochore 2 4.21 0.011633 12.969466
GOTERM_BP_DIRECT GO:0031145∼anaphase-promoting complex-dependent catabolic process 2 4.21 0.013559 14.961799
GOTERM_BP_DIRECT GO:0006268∼DNA unwinding involved in DNA replication 2 4.21 0.015482 16.908679
GOTERM_BP_DIRECT GO:0007095∼mitotic G2 DNA damage checkpoint 2 4.21 0.019316 20.670192
GOTERM_BP_DIRECT GO:0007076∼mitotic chromosome condensation 2 4.21 0.021228 22.486821
GOTERM_BP_DIRECT GO:0000070∼mitotic sister chromatid segregation 2 4.21 0.034511 34.093744
GOTERM_BP_DIRECT GO:0001578∼microtubule bundle formation 2 4.21 0.038274 37.079667
GOTERM_BP_DIRECT GO:0000281∼mitotic cytokinesis 2 4.21 0.040151 38.521683
GOTERM_BP_DIRECT GO:0006270∼DNA replication initiation 2 4.21 0.040151 38.521683
Down-regulated GOTERM_MF_DIRECT GO:0005198∼structural molecule activity 9 6.88 5.12E−6 4.557253
GOTERM_MF_DIRECT GO:0004252∼serine-type endopeptidase activity 7 5.35 1.02E−4 0.004512
GOTERM_MF_DIRECT GO:0008201∼heparin binding 6 4.59 1.73E−4 0.187501
GOTERM_MF_DIRECT GO:0005496∼steroid binding 3 2.29 0.003639 3.880030
GOTERM_MF_DIRECT GO:0004962∼endothelin receptor activity 2 1.53 0.015293 11.655613
GOTERM_MF_DIRECT GO:0003707∼steroid hormone receptor activity 3 2.29 0.022939 31.330301
GOTERM_CC_DIRECT GO:0005615∼extracellular space 25 19.12 7.92E−11 7.97E−8
GOTERM_CC_DIRECT GO:0070062∼extracellular exosome 39 29.82 1.45E−10 4.43E−9
GOTERM_CC_DIRECT GO:0005576∼extracellular region 12 9.18 2.40E−6 0.002416
GOTERM_CC_DIRECT GO:0001533∼cornified envelope 5 3.82 4.01E−5 0.040335
GOTERM_CC_DIRECT GO:0005578∼proteinaceous extracellular matrix 7 5.35 2.35E−4 0.236029
GOTERM_CC_DIRECT GO:0045095∼keratin filament 4 3.06 0.002188 2.179044
GOTERM_CC_DIRECT GO:0042567∼insulin-like growth factor ternary complex 2 1.53 0.023333 21.135448
GOTERM_CC_DIRECT GO:0031012∼extracellular matrix 4 3.06 0.023982 21.661062
GOTERM_CC_DIRECT GO:0001527∼microfibril 2 1.53 0.034797 29.965502
GOTERM_CC_DIRECT GO:0042581∼specific granule 2 1.53 0.062878 47.957744
GOTERM_CC_DIRECT GO:0016323∼basolateral plasma membrane 3 2.29 0.087573 60.215342
GOTERM_BP_DIRECT GO:0018149∼peptide cross-linking 5 3.82 6.99E−4 0.098265
GOTERM_BP_DIRECT GO:0030216∼keratinocyte differentiation 5 3.82 3.21E−4 0.451079
GOTERM_BP_DIRECT GO:0007565∼female pregnancy 3 2.29 0.001635 2.274249
GOTERM_BP_DIRECT GO:0008284∼positive regulation of cell proliferation 7 5.35 0.002416 3.344514
GOTERM_BP_DIRECT GO:0045840∼positive regulation of mitotic nuclear division 3 2.29 0.004434 6.057636
GOTERM_BP_DIRECT GO:0048146∼positive regulation of fibroblast proliferation 3 2.29 0.015351 19.550011
GOTERM_BP_DIRECT GO:0006955∼immune response 5 3.82 0.016764 21.157726
GOTERM_BP_DIRECT GO:0001558∼regulation of cell growth 3 2.29 0.018030 22.573586
GOTERM_BP_DIRECT GO:0001755∼neural crest cell migration 3 2.29 0.0189638 23.602523
GOTERM_BP_DIRECT GO:0014826∼vein smooth muscle contraction 2 1.53 0.022138 27.006079
GOTERM_BP_DIRECT GO:0001775∼cell activation 2 1.53 0.033025 37.638886
GOTERM_BP_DIRECT GO:0014068∼positive regulation of phosphatidylinositol 3-kinase signaling 3 2.29 0.034030 38.544070
GOTERM_BP_DIRECT GO:0007267∼cell–cell signaling 3 2.29 0.042835 45.968556
GOTERM_BP_DIRECT GO:0021952∼central nervous system projection neuron axonogenesis 2 1.53 0.043793 46.724165
GOTERM_BP_DIRECT GO:0030198∼extracellular matrix organization 3 2.29 0.048207 50.079668
GOTERM_BP_DIRECT GO:0048484∼enteric nervous system development 2 1.53 0.049132 50.758144
GOTERM_BP_DIRECT GO:0043568∼positive regulation of insulin-like growth factor receptor signaling pathway 2 1.53 0.049132 50.758144
GOTERM_BP_DIRECT GO:0005978∼glycogen biosynthetic process 2 1.53 0.075392 66.786495
GOTERM_BP_DIRECT GO:0006885∼regulation of pH 2 1.53 0.075392 66.786495
GOTERM_BP_DIRECT GO:0010596∼negative regulation of endothelial cell migration 2 1.53 0.075392 66.786595
GOTERM_BP_DIRECT GO:0031290∼retinal ganglion cell axon guidance 2 1.53 0.080557 69.302524
GOTERM_BP_DIRECT GO:0010906∼regulation of glucose metabolic process 2 1.53 0.090803 73.777717
GOTERM_BP_DIRECT GO:0048662∼negative regulation of smooth muscle cell proliferation 2 1.53 0.095883 75.764591
GOTERM_BP_DIRECT GO:0048675∼axon extension 2 1.53 0.095883 75.764591