Table 3.
Stratified analysis of ERCC6 rs3750751 in the three cohorts of our Breast and Prostate Cancer Consortium (BPC3) dataset, namely Prostate, Lung, and olorectal Cancer (PLCO), European Prospective Investigation into Cancer and Nutrition (EPIC), and Polish Breast Cancer Study (PBCS).
| Study | SNP rs3750751 |
Alleles | Case (N = 255) | Case % | Control (N = 340) | Control % | OR (95% CI) | p-value |
|---|---|---|---|---|---|---|---|---|
| PLCO | GG | 211 | 82.75 | 283 | 83.24 | 1 | ||
| GA | 40 | 15.70 | 55 | 16.18 | 1.04 (0.66–1.63) | 0.87 | ||
| AA | 4 | 1.57 | 2 | 0.59 | 2.78 (0.50–15.39) | 0.25 | ||
| EPIC | Case (N = 368) | Case % | Control (N = 354) | Control % | ||||
| GG | 303 | 82.34 | 294 | 83.05 | 1 | |||
| GA | 65 | 17.66 | 58 | 16.38 | 1.25 (0.64–2.45) | 0.51 | ||
| AA | 0 | 0.00 | 2 | 0.56 | NA | NA | ||
| PBCS | Case (N = 354) | Case % | Control (N = 332) | Control % | ||||
| GG | 298 | 84.18 | 302 | 90.96 | 1 | |||
| GA | 56 | 15.82 | 30 | 9.04 | 1.88 (1.17–3.02) | 0.009 | ||
| AA | 0 | 0.00 | 0 | 0.00 | NA | NA |
Unconditional logistic regression models adjusted for family history of breast cancer and restricted to Caucasian subjects ≥ 50 years.
NA Not analyzed due to small number of subjects (cells with 0 value).