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. 2020 Dec 4;10:21309. doi: 10.1038/s41598-020-78269-3

Table 1.

Two hits from the CarD-DAOTA screen and three CCG-249580 analogues.

Name Structure CarD-BODIPY-FL assay CarD-DAOTA assay
CCG sample IC50 (µM) Powder sample IC50 (µM) CCG sample IC50 (µM) Powder sample IC50 (µM)
CCG-237488 graphic file with name 41598_2020_78269_Figa_HTML.gif 25 ND 20 ND
CCG-249580 graphic file with name 41598_2020_78269_Figb_HTML.gif 263 202 32 45
019–738-824 graphic file with name 41598_2020_78269_Figc_HTML.gif N/A  > 100* N/A  > 100
008–371-831 graphic file with name 41598_2020_78269_Figd_HTML.gif N/A  > 100 N/A  > 100
046–418-303 (Ridinilazole) graphic file with name 41598_2020_78269_Fige_HTML.gif N/A  > 100 N/A  > 100

N/A: not applicable, compounds were not in CCG library. N/D: not determined.

*Compounds were inactive up to 100 µM. They exhibited inhibition above 100 µM which is likely artifactual due to compound aggregation.