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. 2020 Dec 1;14:5315–5324. doi: 10.2147/DDDT.S278414

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© 2020 Li et al.

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β-mangostin inhibits growth of glioma cells in vivo. Subcutaneous transplantation tumor model of C6 cells is conducted to determine the effect of β-mangostin in vivo. (A) Schematic diagram of tumors in treatment group and control group on day 29. (B-C) Tumor volume and body weight in mice comparing between the treatment and control groups. (D) Immunohistochemical detection of Cleaved Caspase-3 and Nrf2 protein levels in the tumor tissues(Scar bar:500 μm). (E) TUNEL immunofluorescence method to detect the apoptosis of tumor tissue(Scar bar:200 μm). Data are the meanμSD for three independent experiments. **P<0.01 vs. controls.