Figure 3.
MPO oxidizes the hydroxytryptamine moiety on the molecular probe resulting in oligomerization and/or covalent addition to matrix proteins, both of which result in increased relaxivity and retention at the site of inflammation. (A). Comparison between axial T1w MR images of mice with a diet-induced NASH phenotype (top row) and steatosis only phenotype (bottom row) before and 60 min post injection with MPO-Gd showing strong enhancement of the liver in the NASH animals that is further reflected in the CNR (contrast-to-noise ratio) maps overlaid on the right (B). Adapted with permission from 32.