Fig. 2.

Exposure to CUMS promotes neuronal expression of TFR stimulated by iron overload. A, B Representative images of immunohistochemistry of TFR (red) stained with MAP2 (cyan), GFAP (green), and DAPI (blue) in cortex (A) and hippocampus (B) (mice with or without exposure to CUMS for 6 weeks, in the last week were randomly selected to be injected with dextran or iron dextran for 6 days). C TFR immunolabeling intensity normalized to the intensity in the control group in cortex and hippocampus (scale bar, 50 μm). Data are presented as the mean ± SEM, n = 6. *P < 0.05 vs control; **P < 0.05 vs any other group.