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. 2020 Dec 4;10:21260. doi: 10.1038/s41598-020-78209-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Concentration of urea in IRI or sham group in (A) plasma, (B) saliva at baseline, 3, 12, 24 and 48 h after ischemia–reperfusion injury, (C) correlation between plasma urea and its salivary concentrations. Concentrations of creatinine in IRI or sham group in (D) plasma, (E) saliva at baseline, 3, 12, 24 and 48 h after ischemia–reperfusion injury, (F) correlation between plasma creatinine and its salivary concentrations. Sham group is shown as white bars and IRI group as black bars. Results are expressed as mean + SD. * denotes p˂0.05, ** denotes p˂0.01, *** denotes p ˂ 0.001 in comparison to the sham group (n = 11 for IRI group, n = 9 for control group).