Table 3.
Results of Mendelian randomisation studies between physical activity exposures and overall COVID-19
| MVPA |
AMPA |
|||||||
|---|---|---|---|---|---|---|---|---|
|
OR (95%CI) |
P |
Pint |
Phet |
OR (95%CI) |
P |
Pint |
Phet |
|
|
One-sample Mendelian randomisation: | ||||||||
| IVW |
0.37 (0.03, 5.08) |
0.46 |
/ |
0.28 |
1.36 (0.20, 9.21) |
0.76 |
/ |
0.13 |
| MR-Egger |
0.01 (8.58×10-8, 1061.38) |
0.43 |
0.53 |
/ |
8.42×10-7 (4.56×10-12, 0.16) |
0.02 |
0.02 |
/ |
|
Multivariable Mendelian randomisation adjusted BMI: | ||||||||
| IVW |
0.39 (0.02, 6.92) |
0.52 |
/ |
0.19 |
0.73 (0.12, 4.25) |
0.73 |
/ |
0.3 |
| MR-Egger | 0.002 (1.60×10-9, 1735.41) | 0.37 | 0.43 | / | 7.66×10-6 (2.04×10-11, 2.88) | 0.07 | 0.08 | / |
COVID-19 – coronavirus disease 2019, MVPA – self-reported moderate-to-vigorous physical activity, AMPA – acceleration vector magnitude physical activity, BMI – body mass index, OR – odds ratio, CI – confidence interval, IVW – inverse variance weighted method, Pint – P value for the intercept of MR-Egger’s test, Phet – P values of χ2 Q test for heterogeneity.