Fig. 1.

Transcriptome profiling of lung samples from uninfected donor and COVID-19 patients. RNA-Seq data (GSE147507) including two uninfected human lung biopsies and two lung samples from COVID-19 deceased patients were analyzed by DESeq2 differential expression analysis. A. Volcano plot of total 1052 differential expression genes with FDR q-value < 0.05. Red color represented upregulated genes in COVID-19 samples with Log2(fold change) > 1.0 and green represented downregulated genes in COVID-19 samples with Log2(fold change) < 1.0. B. Metascape pathway enrichment of 537 upregulated genes. C. Enrichment plots of GSEA correlation analyses for the whole gene expression profile of COVID-19 and donor lung samples by using curated gene sets (c2.all.v7.1.symbols.gmt) and cell marker gene set (CellMarker). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)