Fig. 3.

Gene-network modules associated with COVID-19 revealed by WGCNA. Whole blood transcriptomic profiling (E-MTAB-8871) by RNA NanoString nCounter for 10 healthy donors and a total of 9 days from illness onset to remission of a COVID-19 patient, with their clinic traits were analyzed. A. Hierarchical cluster dendrogram showing different modules based on the unsupervised hierarchical clustering. B. Heatmap of the correlation between modules and clinical traits. Red indicates positive correlation, and blue indicates negative correlation. Person correlation value and P-value were shown in each heatmap. C-D. Expanded view of the expression of top 30 hub genes (weight analysis) in brown and turquoise modules across healthy donors (shown as an average) and each day of illness progression of patient case 1. E. Tachycardia and oxygen saturation traits of 2 to 11 day after illness onset of patient case 1. F-G. PPI network of top 30 hub genes in brown and turquoise modules. Node color intensity indicates the weight value in the weighted gene co-expression network. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)