Table 1.
Other Chinese Medicine Monomer Reversers
| Name | Target Genes/Proteins | Pathway | Chemotherapeutic Agent | Author |
|---|---|---|---|---|
| Astragaloside-Ⅳ | MDR1, p-gp | – | DDP | Ye,201751 |
| Aqueous Extract of Taxus Chinensis | Her-2 | PI3K/AKT | Trachuzumab | Wang,201952 |
| Matrine | mir-7, mir-125b, mir-200a, mir-200b, mir-200c, mir-146a | – | DDP | Li,201553 |
| Neferine | Bcl-2 | – | VCR | Shi,201254 |
| Paeoniflorin | MDR1, Bcl-xl, Bcl-2 | NF-κB | VCR | Fang,201255 |
| Bufalin | Bax, Bcl-2 | Akt and the downstream molecules-GSK-3β, mTOR, S6K, 4EBP1 | DDP | Zhang,201256 Zhao,201657 |
| Oleanolic acid | Bax, Bcl-2, Caspase-3 | – | DDP | Li,200958 Li,201059 |
| Avicularin | Bax, BOK, Caspase-3, PARP | – | DDP | Guo,201860 |
| Peiminine | Cyclin D1, PARP | EGFR/FAK | ADR | Tang,201861 |
| Tetramethylpyrazine | MDR1, GST-π | – | ADR | Yang,201562 |
| Sophoridine | B7-H1 | – | DDP | Deng,201363 |
| Triptolide | HSPA1A, 2HSPA1B/mir-21, Bcl-2 | – | Apatinib/DDP | Teng,201864 Long.201265 |
| Gambogic acid | Surviving | – | Docetaxel | Wang,200866 |