Table 1.
Demographic Characteristics of the Patients and Caregivers and PD Clinical Characteristics
| LCIG (n=53) | CSAI (n=19) | CU (n=54) | P value *, ** | |
|---|---|---|---|---|
| Patients Demographics | ||||
| Age (years); mean ± SD (range) | 70.26 ± 7.1 (53–84) | 66.0 ± 6.6 (54–77) | 69.57 ± 9.1 (42–88) | |
| Male; n (%) | 25 (47%) | 10 (53%) | 29 (54%) | |
| PD Characteristics | ||||
| Hoehn & Yahr in OFF, N (%) | *0.037 | |||
| −1 | 6 (11%) | 1 (5%) | 0 | ** <0.001 |
| −1.5 | 37 (70%) | 8 (42%) | 9 (17%) | |
| −2 | 9 (17%) | 8 (42%) | 36 (67%) | |
| −2.5 | 1 (2%) | 2 (11%) | 8 (15%) | |
| −3 | 0 | 0 | 1 (2%) | |
| −4 | ||||
| PD duration (years), mean ± SD, (range) | 16.38 ± 5.8 (7–33) | 13.58 ± 4.1 (8–21) | 12.83 ± 5.1 (4–35) | *0.085 **0.0003 |
| Duration of motor fluctuations (years), mean ± SD, (range) | 8.36 ± 4.8 (1–26) | 5.47 ± 3.5 (2–14) | 5.22 ± 4.1 (1–25) | *0.0099 ** <0.0001 |
| Caregivers Characteristics | ||||
| Age (years); mean ± SD (range) | 59.19 ± 13.2 (36–84) | 60.26 ± 12.9 (29–78) | 55.89 ± 12.6 (29–85) | |
| Female; n (%) | 30 (56%) | 15 (79%) | 43 (80%) | |
| Daily duration of supporting assistance | N=53 | N=19 | N=52 | |
| Day and night (24 hours) | 26 (49%) | 12 (63%) | 29 (56%) | *0.1783 **0.2013 |
| During daytime | 8 (15%) | 4 (21%) | 9 (17%) | *0.2762 **0.6155 |
| From 3 to 6 hours per day | 19 (36%) | 3 (16%) | 14 (27%) | *0.3075 **0.0003 |
| Caregiver burden | ||||
| ZBI score (mean ± SD) | 29.6 ± 14.42 | 35.8 ± 20.15 | 31.4 ±16.0 | *0.328 **0.535 |
Notes: *LCIG vs. CSAI; **LCIG vs. CU; Two-Sample T-test and Wilcoxon Two Sample Test for PD characteristic analysis; Chi Square Test or Fisher Test for daily time spent for the assistance; *LCIG vs. CSAI; **LCIG vs. CU; Bold indicates statistical significance.
Abbreviations: LCIG, levodopa/carbidopa intestinal gel; CSAI, subcutaneous apomorphine infusion; CU, care as usual; SD, standard deviation; N/A, not available; ZBI, Zarit Burden Interview.