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. 2020 May 20;13(6):1161–1169. doi: 10.1111/cts.12800

Figure 4.

Figure 4

Relationships between individual pharmacokinetic parameters vs. pharmacodynamic parameters. (a) maximum concentration (Cmax) of interleukin (IL)‐7 vs. maximum absolute lymphocyte count (ΔEmax), (b) Cmax of IL‐7 vs. absolute lymphocyte count‐time curve until the last sampling time (ΔAUEC), (c) area under the serum concentration vs. time curve (AUC) from time zero to the last measurable time‐point (AUClast) of IL‐7 vs. ΔEmax, (d) AUClast of IL‐7 vs. ΔAUEC of absolute lymphocyte count after a single subcutaneous or intramuscular administration of IL‐7 (● = 20 μg/kg s.c., N = 8; □ = 60 μg/kg s.c., N = 8; ▲ = 60 μg/kg i.m., N = 8).