Table 1.
Pharmacokinetic parameters of hIL‐7‐hyFc after a single subcutaneous and intramuscular administration
| Pharmacokinetic parameters | 20 μg/kg s.c. (N = 8) | 60 μg/kg s.c. (N = 8) | 60 μg/kg i.m. (N = 8) |
|---|---|---|---|
| Tmax, hour | 42.0 (6.0–72.0) | 36.0 (4.0–72.0) | 4.0 (2.0–35.8) |
| Cmax, μg/L | 0.1 ± 0.0 | 0.5 ± 0.3 | 1.2 ± 0.5 |
| AUClast, h∙μg/L | 10.2 ± 2.0 | 31.0 ± 8.4 | 64.9 ± 25.1 |
| AUCinf, h∙μg/L | 12.4 ± 2.8 | 33.3 ± 8.8 | 83.4 ± 57.9 |
| t 1/2, hour | 52.7 ± 32.1 | 26.8 ± 15.6 | 63.3 ± 49.4 |
| CL/F, L/hour | 101.3 ± 25.2 | 128.4 ± 31.4 | 55.5 ± 20.8 |
| V d/F, L | 7243.3 ± 3500.7 | 5097.8 ± 3707.5 | 4577.9 ± 3666.4 |
AUCinf, area under the serum concentration vs. time curve from time zero to infinity; AUClast, area under the serum concentration vs. time curve from time zero to the last measurable time‐point; CL/F, apparent clearance; Cmax, maximum concentration; t 1/2, terminal half‐life; Tmax, time to reach maximum concentration; V d/F, apparent volume of distribution.
All data are presented as mean ± SD, except for Tmax, which are presented as median (minimum–maximum).