Table 3.
Pharmacokinetic variables of allopurinol and febuxostat on day 6 of 300 mg allopurinol once daily, or on day 3 of 120 mg febuxostat once daily in 10 healthy volunteers
| Variable | Geometric mean (geometric CV) |
|---|---|
| Allopurinol | |
| Cmax, µg/mL | 2.0 (21%) |
| t ½, hour | 1.3 (50%) |
| AUC0–24, µg·hour/mL | 5.7 (46%) |
| Febuxostat | |
| Cmax, µg/mL | 4.3 (49%) |
| t ½, hour | 6.0 (21%) |
| AUC0–24, µg·hour/mL | 12.3 (39%) |
AUC, area under the plasma concentration‐time curve from zero to 24 hours; Cmax, peak plasma concentration; CV, coefficient of variation; t ½, elimination half‐life.