Figure 3.

The new approach provides more accurate prediction of hepatic clearance ( ${\text{CL}}_{\mathrm{h}}$ ) than the canonical approach. (a) Relationships between measured in vivo ${\text{CL}}_{\mathrm{h}}$ and predicted ${\text{CL}}_{\mathrm{h}}$ (Table 2 ). Here, the dispersion model is used to predict ${\text{CL}}_{\mathrm{h}}$ based on intrinsic clearance of the liver ( ${\text{CL}}_{\text{int}}^{\text{liver}}$ ) estimated by either the canonical or the new approach (see Methods and Table 2 for details). The solid and dashed lines represent the line of identity and twofold error, respectively. (b) Precision error of ${\text{CL}}_{\mathrm{h}}$ predicted with the canonical and new approaches. Pa, paclitaxel; Cy, cyclosporine; Fe, felodipine; In, indinavir; Ca, cabazitaxel; Mi, midazolam; Va, valspodar; Do, docetaxel; Co, coumarin; Sa, saquinavir; Pr, propafenone.