Table 3.

Accuracy and precision of predicted CL_h using the canonical and new approaches

	Dispersion model		Well‐stirred model		Parallel tube model
	Canonical	New	Canonical	New	Canonical	New
AFE	2.46	1.83	2.14	1.58	2.57	1.94
AAFE	2.46	1.84	2.14	1.62	2.57	1.95
RMSE (mL/min)	709	433	560	305	753	494
R‐RMSE	2.06	1.15	1.67	0.88	2.20	1.28

AAFE, absolute average fold error; AFE, average fold error; CL_h, hepatic clearance; RMSE, root mean squared error; R‐RMSE, relative‐root mean squared error.