Table 2.
UGT1A1 phenotype inference based on genotype information
| UGT1A1 | |
|---|---|
| Normal metabolizers | |
| *1/*1, *1/*36, *36/*36 | 2 reference function (*1/*1) and/or increased function allele (*36) |
| rs887829 C/C | rs887829 C/C homozygosity |
| Intermediate metabolizers | |
| *1/*28, *1/*37, *36/*28, *36/*37 | 1 reference function (*1) or increased function allele (*36) and 1 decreased function allele (*6, *28, *37) |
| rs887829 C/T (*1/*80) | rs887829 C/T heterozygosity |
| Poor metabolizers | |
| *28/*28, *28/*37, *37/*37, *6/*6 | 2 decreased function alleles (*6, *28, *37). |
| rs887829 T/T (*80/*80) | rs887829 T/T homozygosity |
Information obtained from Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline on atazanavir and UGT1A1. 73
UGT1A1, UDP glucuronosyltransferase family 1 member A1.