Table 4.

Clinical Outcomes of Peroral Endoscopic Myotomy for Achalasia and Non-Achalasia Esophageal Motility Disorders

Study	Type of motility disorder	Patient (n)	Clinical responses (%)	Mean follow-up (mo)	Major complication (%)
Li et al. (2013) [32]	Achalasia	238	95.0	8.5	0
Cai et al. (2014) [33]	Achalasia	100	96.5	11.5	0
Stavropoulos et al. (2013) [13]	Achalasia	100	97.0	13.3	0
Ramchandani et al. (2016) [29]	Achalasia	220	92.0	13.4	0
Chen et al. (2015) [34]	Achalasia (pediatric)	27	100.0	24.6	0
Inoue et al. (2015) [35]	Achalasia	500	91.0	36.0	3.2
	DES	9	100.0
Li et al. (2018) [36]	Achalasia	564	87.1	49.0	6.4
Teitelbaum et al. (2018) [37]	Achalasia (type I)	8	88.0	65.0	4.7
	Achalasia (type II)	15	80.0
	EGJOO	5	60.0
	DES	1	100.0
Werner et al. (2019) [38]	Achalasia	112	83.0	24.0	2.7
Brewer Gutierrez et al. (2020) [39]	Achalasiaa)	146	95.2	55.0	5.5b)
Shiwaku et al. (2020) [40]	Achalasiaa)	1,346	94.7	12.0	0
Khashab et al. (2015) [16]	Achalasia (type III)	54	96.3	7.8	7.4b)
	DES	9	100.0		22.2b)
	JHE	10	70.0		20.0b)
Sharata et al. (2015) [28]	Achalasiaa)	75	97.8	16	6.0b)
	DES, NE, isolated hypertensive non-relaxing LES	25	70.8
Khan et al. (2017) [41]	Achalasiaa) (type III)	116	92.0	3–36	11.0b)
	JHE	37	72.0		16.0b)
	DES	18	88.0		14.0b)
Khashab et al. (2018) [17]	DES, JHE	35	84.9	9.1	20.0b)
	EGJOO	15	93.3	6.5	13.3b)
Filicori et al. (2019) [42]	DES	11	91.0	48.0	10.0b)
	EGJOO	14
	Hypercontractile esophagus	15
Bernardot et al. (2020) [43]	NAEMD (JHE, SED, EGJOO)	30	63.2	6	26.7b)
	Achalasia (type I, II)	30	95.5		20.0b)
	Achalasia (type III)	30	87.0		33.4b)

DES, diffuse esophageal spasm; EGJOO, esophagogastric junction outflow obstruction; JHE, jackhammer esophagus; LES, lower esophageal sphincter; NAEMD, non-achalasia esophageal motility disorder; NE, nutcracker esophagus; SED, spastic esophageal disorder.

^a)Previous failed treatment was included.

^b)Minor complication rate was included.