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Overview of adverse events.
| Adverse events | All grades (%) | Grade 1 (%) | Grade 2 (%) | Grade 3 (%) | Grade 4 (%) |
|---|---|---|---|---|---|
| Hypertension | 71 | 19 | 26 | 26 | 0 |
| Decreased weight | 70 | 30 | 33 | 7 | 0 |
| Fatigue | 59 | 33 | 26 | 0 | 0 |
| Proteinuria | 48 | 29 | 19 | 0 | 0 |
| Diarrhea | 44 | 26 | 9 | 7 | 2 |
| Decreased appetite | 23 | 14 | 9 | 0 | 0 |
| Asthenia | 21 | 19 | 2 | 0 | 0 |
| Palmar-plantar erythrodysesthesia syndrome | 14 | 12 | 0 | 2 | 0 |
| Electrolyte derailment | 14 | 12 | 2 | 0 | 0 |
| Vomiting | 7 | 7 | 0 | 0 | 0 |
| QT-prolongation | 5 | 5 | 0 | 0 | 0 |
| Mouth dryness | 5 | 5 | 0 | 0 | 0 |
| Liver dysfunction | 2 | 0 | 2 | 0 | 0 |
