Figure 5.

Tetrandrine (Tet) decreases osteoclast bone resorption and the formation of F-actin rings. (a) F-actin rings and nuclei were observed under a confocal microscope (scale bar = 100 μm). (b) Images of the bone resorption pits in each group (scale bar = 100 μm). (c) Quantification of bone resorption area (^∗p < 0.05, ^∗∗p < 0.01 compared with the control group; n = 4 per group). Data are the means of at least three independent experiments with similar results. The red arrows indicate the F-actin rings.