TABLE 1.

Peak SNR and AUC ratios (total metabolite signal divided by total pyruvate signal and normalized by voxel volume) for lactate, alanine, and bicarbonate in rat kidney experiments (n = 4) shown in Figure 2 and Supporting Information Figure S1

	Constant resolution		Variable resolution
	Peak SNR	AUC Ratio	Peak SNR	AUC Ratio
Pyruvate	57.4 ± 21.0	N/A	55.3 ± 13.6	N/A
Lactate	4.3 ± 0.8*	0.143 ± 0.054	14.9 ± 2.3*	0.120 ± 0.034
Alanine	2.4 ± 1.0*	0.089 ± 0.042	20.9 ± 4.7*	0.070 ± 0.016
Bicarbonate	0.9 ± 0.3*	0.057 ± 0.031*	5.4 ± 2.4*	0.017 ± 0.010*
Noise ROI	N/A	0.054 ± 0.030	N/A	0.005 ± 0.002

Constant resolution data sets were acquired at 2.5 × 2.5 mm² for all metabolites. For variable resolution data sets, pyruvate was acquired at 2.5 × 2.5 mm² in-plane resolution, while lactate was acquired at 5.0 × 5.0 mm² and bicarbonate and alanine at 7.5 × 7.5 mm². For reference, a noise ROI shows the detectable limit for the constant resolution and variable-resolution at 7.5 × 7.5 mm². There was a significant difference (*P < .05) between the constant and variable resolution bicarbonate-to-pyruvate ratio, as well as the peak lactate, alanine, and bicarbonate SNR values.