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INSTI obstruction of tDNA positioning for strand transfer. The structures of the HIV-1 strand transfer complex (PDB code 5U1C, gray) [22] and 4d-bound intasome (PDB code 6PUY, cyan with magenta INSTI) were superimposed via Cα positions of active site residues Asp64, Asp116, and Glu152 using PyMOL [40]. Note the extensive overlap between the hexanol substituent of compound 4d with tDNA. Other labeling as in Figure 1B and 1C.
