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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: FASEB J. 2020 Aug 14;34(10):13521–13532. doi: 10.1096/fj.202001145R

FIGURE 4.

FIGURE 4

MaR1 induces an osteoinductive secretome in macrophages from aged mice. A, Bone marrow-derived macrophages from aged mice were treated with vehicle or MaR1 and then used to condition osteogenic media. Osteogenic media was subsequently used to differentiate BMSCs from 24-month old mice. After 14 days of differentiation, wells were (B) washed, fixed, and stained for alkaline phosphatase (ALP) or (C) assessed for osteogenic transcripts using RT-PCR. n = 6 per group. Data are expressed as mean ± standard deviation. *P < .05