Table 1.
The HRs (95% CIs) of incident ischemic stroke by Cardiovascular Health Metrics and sex.
| Characteristics* | Cardiovascular health metrics | P trend | |||||
|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5–6 | ||
| MALES | |||||||
| Cases | 8 | 23 | 47 | 42 | 21 | 7 | |
| Number of participants | 84 | 348 | 647 | 700 | 401 | 147 | |
| M0† | 1 [Reference] | 0.73 (0.32–1.64) |
0.35 (0.16–0.75) |
0.41 (0.19–0.88) |
0.37 (0.16–0.85) |
0.22 (0.07–0.64) |
0.006 |
| M1‡ | 1 [Reference] | 0.70 (0.31–1.58) |
0.32 (0.15–0.70) |
0.38 (0.18–0.83) |
0.34 (0.15–0.79) |
0.21 (0.07–0.63) |
0.005 |
| M2§ | 1 [Reference] | 0.80 (031–2.07) |
0.37 (0.14–0.94) |
0.45 (0.17–1.17) |
0.37 (0.12–1.08) |
0.22 (0.06–0.81) |
0.019 |
| FEMALES | |||||||
| Cases | 4 | 31 | 52 | 60 | 34 | 11 | |
| Number of participants | 38 | 284 | 598 | 741 | 506 | 168 | |
| M0† | 1 [Reference] | 0.47 (0.16–1.36) |
0.42 (0.15–1.17) |
0.35 (0.12–0.99) |
0.33 (0.11–0.95) |
0.31 (0.10–1.00) |
0.036 |
| M1‡ | 1 [Reference] | 0.47 (0.16–1.36) |
0.41 (0.14–1.14) |
0.35 (0.12–0.98) |
0.32 (0.11–0.93) |
0.31 (0.09–1.00) |
0.033 |
| M2§ | 1 [Reference] | 0.42 (0.14–1.29) |
0.30 (0.10–0.88) |
0.25 (0.08–0.77) |
0.25 (0.08–0.75) |
0.25 (0.07–0.86) |
0.020 |
| TOTAL | |||||||
| Cases | 12 | 54 | 99 | 102 | 55 | 18 | |
| Number of participants | 122 | 632 | 1,245 | 1,441 | 907 | 315 | |
| M0† | 1 [Reference] | 0.57 (0.30–1.07) |
0.39 (0.21–0.71) |
0.37 (0.20–0.69) |
0.36 (0.19–0.67) |
0.28 (0.13–0.59) |
<0.001 |
| M1‡ | 1 [Reference] | 0.55 (0.29–1.04) |
0.37 (0.20–0.68) |
0.36 (0.19–0.66) |
0.34 (0.17–0.64) |
0.27 (0.13–0.58) |
<0.001 |
| M2§ | 1 [Reference] | 0.62 (0.31–1.25) |
0.37 (0.19–0.74) |
0.37 (0.18–0.74) |
0.34 (0.16–0.71) |
0.28 (0.12–0.63) |
<0.001 |
BMI, body mass index.
*
All non-pregnant participants older than 20 years with available cardiovascular health metrics were included.
†
Not adjusted.
‡
Adjusted for age, sex.
§
Adjusted for age, sex, education, alcohol consumption, diabetes mellitus, depression, family history of stroke, years of hypertension, antihypertensive medication, low density lipoprotein, systolic blood pressure, diastolic blood pressure, uric acid, triglyceride, total homocysteine and creatinine.