Table 3.
The HRs (95% CIs) of incident ischemic stroke by Cardiovascular Health Metrics and age, hypertension duration, controlled blood pressure, and homocysteine.
| Characteristics* | Cardiovascular health metrics | P trend† | P for interaction | |||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5–6 | |||
| Age, years‡ | 0.506 | |||||||
| <60 | 1.00 | 0.82 (0.24–2.84) |
0.36 (0.10–1.27) |
0.46 (0.13–1.56) |
0.39 (0.11–1.42) |
0.14 (0.03–0.74) |
0.020 | |
| ≥60 | 1.00 | 0.52 (0.23–1.17) |
0.33 (0.15–0.71) |
0.31 (0.14–0.68) |
0.31 (0.13–0.70) |
0.35 (0.14–0.89) |
0.025 | |
| Hypertension duration, years‡ | 0.578 | |||||||
| <5 | 1.00 | 1.52 (0.51–4.54) |
0.83 (0.30–2.29) |
0.56 (0.20–1.57) |
0.77 (0.25–2.36) |
0.32 (0.09–1.12) |
0.009 | |
| ≥5 | 1.00 | 0.32 (0.13–0.76) |
0.18 (0.08–0.41) |
0.20 (0.08–0.49) |
0.15 (0.06–0.38) |
0.17 (0.06–0.53) |
0.006 | |
| Controlled blood pressure, mmHg‡ | 0.508 | |||||||
| SBP < 130 or DBP < 80 | 1.00 | 0.99 (0.34–2.95) |
0.51 (0.17–1.48) |
0.58 (0.20–1.67) |
0.60 (0.20–1.78) |
0.41 (0.12–1.38) |
0.108 | |
| SBP≥130 or DBP≥80 | 1.00 | 0.32 (0.12–0.85) |
0.21 (0.08–0.52) |
0.18 (0.07–0.48) |
0.16 (0.06–0.47) |
0.21 (0.07–0.67) |
0.007 | |
| Homocysteine, μmol/L‡ | 0.412 | |||||||
| <15 | 1.00 | 0.21 (0.09–0.49) |
0.11 (0.05–0.24) |
0.12 (0.05–0.27) |
0.11 (0.05–0.26) |
0.13 (0.05–0.35) |
0.025 | |
| ≥15 | 1.00 | 1.21 (0.38–3.84) |
0.87 (0.28–2.65) |
0.65 (0.19–2.15) |
0.61 (0.17–2.19) |
0.30 (0.06–1.40) |
0.012 | |
SBP, systolic blood pressure; DBP, diastolic blood pressure.
*
All non-pregnant parti5cipants older than 20 years with available cardiovascular health metrics were included.
†
Trends were analyzed by logistic regression model with adjustment for age and sex.
‡
Adjusted for age, sex, education, alcohol consumption, diabetes mellitus, depression, family history of stroke, years of hypertension, antihypertensive medication, low density lipoprotein, systolic blood pressure, diastolic blood pressure, uric acid, triglyceride, total homocysteine and creatinne.