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. 2020 Nov 23;11:577927. doi: 10.3389/fneur.2020.577927

Figure 2.

Figure 2

I/R injury induced canonical and non-canonical inflammasome dependent pyroptosis in ischemic cortex. (A) Band intensity of cleaved-GSDMD, active caspase-1, and caspase-11 at 12, 24, 48, 72 h post I/R injury. (B–D) Relative expression of cleaved-GSDMD (B), active caspase-1 (p20) (C), and caspase-11 (D) at 12, 24, 48, 72 h post I/R injury. n = 5. (E,F) The levels of IL-1β and IL-18 in the cortex were measured by ELISA at 12, 24, 48, 72 h post I/R injury. n = 5. *P < 0.05, **P < 0.01, ***P < 0.001, vs. the Sham group. I/R, ischemia reperfusion; GSDMD, gasdermin D.