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. 2020 Nov 23;11:577927. doi: 10.3389/fneur.2020.577927

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Copyright © 2020 Wang, Sun, Ru, Wang, Huang, Ruan, Lin, Jin, Zhuge and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ablation of GSDMD improves neurological outcome post I/R injury. (A) CBF in the MCAO modeling. n = 5. (B–D) Blood glucose (B), blood gas (C), and body temperature (D) of the mice before and after MCAO modeling. n = 5. (E,F) Representative images of TTC staining in four sequential brain slices from WT and gsdmd^−/− mice. n = 5. (G) Neurological recovery was evaluated by mNSS on days 1, 7, 14, 21, and 28 post MCAO/R. n = 12. (H,I) Immunohistochemical staining of brain tissue on day 1 post MCAO/R. n = 5. **P < 0.01, ***P < 0.001, vs. the WT group. GSDMD, gasdermin D; I/R, ischemia reperfusion; MCAO, middle cerebral artery occlusion; CBF, cerebral blood flow; mNSS, modified neurological severity score; WT, wild type.