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. 2020 Nov 23;11:555006. doi: 10.3389/fphys.2020.555006

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Copyright © 2020 Ma, Tang, Gu, Hu, Zhang, Wu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The roles of PDGF-B in cell proliferation and angiogenesis are attenuated by inhibition of the Erk pathway. (A,B) The increases in cell viability (A) and BrdU incorporation (B) induced by PDGF-B were abolished by U0126. (C) The increased expression of PCNA induced by PDGF-B was weakened by U0126. (D,E) The cell migration (D) and tube formation (E) enhancements induced by PDGF-B treatment were antagonized by inhibition of the Erk pathway. (F) A schematic representation of PDGF-regulated cell proliferation and angiogenesis in retinal microvascular endothelial cells (RMECs) is shown. ^*indicates p < 0.05.